obsidian/💻 Hyperblog/Work/seed oil claims - oxidized plaque lipids.md

Claim

Seed oils are unhealthy because most lipids found in atheromas are oxidized.

Rebuttal

This claim is merely mechanistic speculation, and is an example of the ecological fallacy. Essentially, it is being posited that merely because atherosclerotic plaques contain high proportions of oxidized linoleic acid (LA), that said LA must have caused the atherosclerotic plaque to begin with. It is true that plaques contain very high proportions of oxidized LA (1)(2). However, we must remember the pathophysiology of atherosclerosis, which involves native low-density lipoproteins particles being irreversibly bound to proteoglycans in the subendothelial space (3)(4). Once bound, oxidation is inevitable. It's unclear that restricting seed oils will actually lead to reduced oxidized lipids in the plaque.

---

References

1. https://pubmed.ncbi.nlm.nih.gov/10397689/
2. https://pubmed.ncbi.nlm.nih.gov/8632720/
3. https://pubmed.ncbi.nlm.nih.gov/9637699/
4. https://pubmed.ncbi.nlm.nih.gov/27472409/

---

Hashtags

#claims #ecological_fallacy #heart_disease #cardiology #low-density_lipoproteins #mechanistic_speculation #proteoglycans #seed_oils
#hyperblog