mirror of
https://gitlab.com/upRootNutrition/obsidian.git
synced 2025-06-15 23:25:13 -05:00
61 lines
No EOL
3 KiB
Markdown
61 lines
No EOL
3 KiB
Markdown
# Lipid Triad
|
||
|
||
https://pubmed.ncbi.nlm.nih.gov/29241485/
|
||
|
||
"Many CVRF-free middle-aged individuals have atherosclerosis. LDL-C, even at levels currently considered normal, is independently associated with the presence and extent of early systemic atherosclerosis in the absence of major CVRFs. These findings support more effective LDL-C lowering for primordial prevention, even in individuals conventionally considered at optimal risk."
|
||
|
||
Lipid combos:
|
||
https://pubmed.ncbi.nlm.nih.gov/25458651/
|
||
|
||
"Aside from isolated hypertriglyceridemia, low levels of HDL-C, high levels of LDL-C, and high levels of TG in any combination were associated with increased risk of CVD."
|
||
|
||
LMHR paper:
|
||
https://pubmed.ncbi.nlm.nih.gov/35106434/
|
||
|
||
"These data suggest that, in contrast to the typical pattern of dyslipidemia, greater LDL cholesterol elevation on a CRD tends to occur in the context of otherwise low cardiometabolic risk."
|
||
|
||
---
|
||
|
||
# LDL Bounty
|
||
|
||
## Criteria
|
||
|
||
1. **HDL Cholesterol of 50 mg/dL or above (≥ 1.29 mmol/L)**
|
||
2. **Triglycerides of 100 mg/dL or below (≤ 1.13 mmol/L)**
|
||
3. **LDL Cholesterol of 130 mg/dL or above (≥ 3.36 mmol/L)**
|
||
4. **Either high Coronary Heart Disease (CHD) or high Cardiovascular Disease (CVD) (see the section below)**
|
||
5. By “**normal**” and “**non-treated**“, I mean:
|
||
- No stratifying by specific genetics
|
||
- No stratifying by drugs (no drug studies)
|
||
- No stratifying by a particular illness in advance of the study. (duh!)
|
||
- _In other words, just a generally broad group of people like [Framingham Offspring](https://www.ncbi.nlm.nih.gov/pubmed/27166203) or the [Jeppesen study](https://www.ncbi.nlm.nih.gov/pubmed/11176761)_
|
||
6. And here’s some fine print that should be obvious, but just in case…
|
||
- The study needs to be published in a reputable journal
|
||
- It has to be dated before this article was posted, of course
|
||
- The study needs to have at least 400 participants that are stratified by this criteria. (The two studies above have over 500)
|
||
- I’d prefer no unusual “modeling” or “adjustments” to alter the data too far from it’s original set. This one goes by the honor system — if you have such a study and it is clearly warranted, I can give it a pass.
|
||
|
||
"High" defined as greater than the average rates of CVD per age group in the American population.
|
||
|
||
### Criticisms
|
||
|
||
1. Vanishingly small population subset. Unreasonable to expect it to have been studied.
|
||
2. If studied in the general population, they won't be keto, so translation to keto subjects may be dubious.
|
||
3. The sheer weight of the evidence in favour of LDL's causal role in ASCVD cuts deeply against the notion that this population subset would be protected to begin with.
|
||
4. Comparing this isolated cohort to the American general population is methodology that is beyond fringe, bordering on insane.
|
||
5. Ultimately if this is taken to be an indication that LDL is fine in this particular context, it would qualify as an appeal to ignorance.
|
||
|
||
---
|
||
|
||
# Hashtags
|
||
|
||
#lipidology
|
||
#lipid_triad
|
||
#LMHR
|
||
#LDL
|
||
#triglycerides
|
||
#HDL
|
||
#clowns
|
||
#clownery
|
||
#debate
|
||
#debate_opponents |