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27 lines
No EOL
2.4 KiB
Markdown
Executable file
27 lines
No EOL
2.4 KiB
Markdown
Executable file
Byrne, Paula, et al. ‘Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-Analysis’. _JAMA Internal Medicine_, Mar. 2022. _Silverchair_, https://doi.org/10.1001/jamainternmed.2022.0134.
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**Link:**
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https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2790055
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**Notes:**
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>- No distinction between time-based and event-based stopping conditions.
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>- Relative risk and absolute risk are answering two different questions.
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>- Included many trials with chronic kidney failure and on hemodialysis (high risk with unclear potential benefit of lipid lowering).
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>- Unclear distinction between high and moderate risk populations, with high risk populations already having achieved significant lipid reductions.
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>- Authors assume linearity in the relationship between LDL and their endpoints (average 3-4 years versus 20 years, when the largest risk reductions seem to be achieved).
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>- Mixed primary and secondary prevention trials.
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**Conclusions:**
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> The results of this meta-analysis suggest that the absolute risk reductions of treatment with statins in terms of all-cause mortality, myocardial infarction, and stroke are modest compared with the relative risk reductions, and the presence of significant heterogeneity reduces the certainty of the evidence. A conclusive association between absolute reductions in LDL-C levels and individual clinical outcomes was not established, and these findings underscore the importance of discussing absolute risk reductions when making informed clinical decisions with individual patients.
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**PDF:**
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[[📂 Media/PDFs/Evaluating_the_Association_Between_Low-Density_Lipoprotein_Cholesterol_Reduction_and_Relative_and_Absolute_Effects_of_Statin_Treatment_A_Systematic_Review_and_Meta-analysis.pdf]]
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| **Endpoints** | **Exposures** | **Populations** | **General** | **People** |
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| ------------- | ------------------ | --------------- | ------------- | ---------- |
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| #coronary_heart_disease | #statins | #humans | #blood_lipids | |
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| #all_cause_mortality | #LDL | #multinational | #disease | |
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| #stroke | #serum_cholesterol | | #clownery | |
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| | | | #clown_papers | | | | | | |
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**** |