obsidian/💻 Hyperblog/Work/seed oil claims - cholestasis.md

Claim

Seed oils are unhealthy because they cause cholestasis.

Rebuttal

While partially true, this claim counts as a red herring, because it's not actually seed oils simpliciter that causes cholestasis. In the LA Veterans Administration Hospital Study, the seed oil group had a dose-dependent increase in gallstones (1). However, the most parsimonious way of explaining the effect is through the elimination of hepatic phytosterols, leading to gallstones, not linoleic acid (2)(3).

Some seed oils, such as corn oil (the primary seed oil investigated in the LA Veterans trial), have extremely high concentrations of phytosterols (4). At the doses investigated, this may be expected to cause issues, but these are not doses that people typically consume, even on the standard american diet.

---

References

1. https://pubmed.ncbi.nlm.nih.gov/4681896/
2. https://pubmed.ncbi.nlm.nih.gov/9437703/
3. https://pubmed.ncbi.nlm.nih.gov/27812789/
4. https://pubmed.ncbi.nlm.nih.gov/31404986/

---

Hashtags

#cholestasis #claims #gallstones #la_veterans #liver_function #phytosterols #red_herring #seed_oils
#hyperblog