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💻 Hyperblog/Work/seed oil claims - oxidized plaque lipids.md

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+# Claim
+
+>Seed oils are unhealthy because most lipids found in atheromas are oxidized.
+
+## Rebuttal
+
+This claim is merely [[mechanistic speculation]], and is an example of the [[ecological fallacy]]. Essentially, it is being posited that merely because atherosclerotic plaques contain high proportions of oxidized [[linoleic acid]] (LA), that said LA must have caused the atherosclerotic plaque to begin with. It is true that plaques contain very high proportions of oxidized LA [(1)](https://pubmed.ncbi.nlm.nih.gov/10397689/)[(2)](https://pubmed.ncbi.nlm.nih.gov/8632720/). However, we must remember the pathophysiology of [[atherosclerosis]], which involves native [[low-density lipoproteins]] particles being irreversibly bound to [[proteoglycans]] in the [[subendothelial space]] [(3)](https://pubmed.ncbi.nlm.nih.gov/9637699/)[(4)](https://pubmed.ncbi.nlm.nih.gov/27472409/). Once bound, oxidation is inevitable. It's unclear that restricting seed oils will actually lead to reduced oxidized lipids in the plaque.
+
+---
+
+## References 
+
+1. https://pubmed.ncbi.nlm.nih.gov/10397689/
+2. https://pubmed.ncbi.nlm.nih.gov/8632720/
+3. https://pubmed.ncbi.nlm.nih.gov/9637699/
+4. https://pubmed.ncbi.nlm.nih.gov/27472409/
+
+---
+
+# Hashtags
+
+#claims
+#ecological_fallacy
+#heart_disease
+#cardiology
+#low-density_lipoproteins
+#mechanistic_speculation
+#proteoglycans
+#seed_oils