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💻 Hyperblog/Work/seed oil claims - cholestasis.md

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+# Claim
+
+>Seed oils are unhealthy because they cause cholestasis.
+
+## Rebuttal
+
+While partially true, this claim counts as a [[red herring]], because it's not actually seed oils simpliciter that causes [[cholestasis]]. In the [[LA Veterans Administration Hospital Study]], the seed oil group had a dose-dependent increase in gallstones [(1)](https://pubmed.ncbi.nlm.nih.gov/4681896/). However, the most parsimonious way of explaining the effect is through hepatic [[phytosterol]] elimination leading to gallstones, not [[linoleic acid]] [(2)](https://pubmed.ncbi.nlm.nih.gov/9437703/)[(3)](https://pubmed.ncbi.nlm.nih.gov/27812789/).
+
+Some seed oils, such as corn oil (the primary seed oil investigated in the LA Veterans trial), have extremely high concentrations of [[phytosterols]] [(4)](https://pubmed.ncbi.nlm.nih.gov/31404986/). At the doses investigated, this may be expected to cause issues, but these are not doses that people typically consume, even on the [[standard american diet]].
+
+---
+
+## References 
+
+1. https://pubmed.ncbi.nlm.nih.gov/4681896/
+2. https://pubmed.ncbi.nlm.nih.gov/9437703/
+3. https://pubmed.ncbi.nlm.nih.gov/27812789/
+4. https://pubmed.ncbi.nlm.nih.gov/31404986/
+
+---
+
+# Hashtags
+
+#cholestasis
+#claims
+#gallstones 
+#la_veterans
+#liver_function 
+#phytosterols
+#red_herring 
+#seed_oils