vault backup: 2024-10-26 15:21:42

🏛️ Home/Obesity epidemic mech-spec.md

@@ -0,0 +1,28 @@
+
+1. **Meal Scheduling**
+	- There are deeply embedded cultural norms about when people should eat.
+	- It may be considered bizarre when people deviate from the traditional 3-meal structure.
+	- These norms may also be reinforced institutionally by work, school, etc.
+2. **Meal Completion**
+	- There may be generational trauma related to food scarcity that still persists despite food abundance.
+	- Norms that made sense in the context of food scarcity could have a detrimental impact in the context of food abundance.
+	- There may be a general cultural ethos that discourages food waste, and encourages consumption beyond one's needs in order to avoid it.
+	- The phrase "finish your plate" is still taught to children.
+3. **Ceremonial Eating**
+	- Celebratory eating is central to nearly every holiday or holiday season.
+	- People may feel out of place for not partaking.
+	- Refusing traditional foods may be viewed as an affront to cultural identity, and could lead to various sorts of cultural friction.
+	- Even non-traditional holidays often incorporate mandatory food elements.
+4. **Social Pressure**
+	- Even outside the context of celebrations or ceremony, food is frequently central to many mundane social events (such as dates or outings).
+	- Refusing to partake can result in awkwardness that many may feel more comfortable avoiding, resulting in consumption beyond one's needs.
+	- People may also feel pressured to match other people's eating pace and quantity, and may feel out of place if they "eat like a bird".
+5. **Portion Size**
+	- Meals may seem less worthwhile if they do not have a high volume and/or calorie to price and/or effort ratio.
+	- Paying the same amount of money for a smaller meal may seem less valuable or economically desirable, and people may have a desire to "get their money's worth".
+	- People might feel more compelled to eat more than they otherwise would when participating in more open-ended, buffet-style dining, in order to justify the cost.
+6. **Hedonic Eating**
+	- Food may be viewed as a form of entertainment or reward, with "treating" oneself with "guilty pleasures" often forming the justification for indulging.
+	- Exciting the palate may be considered one of the primary reasons for eating.
+	- Nearly all food advertising emphasizes the pleasure of eating certain foods, which may be an indication of consumer motivations when buying these foods.
+	- Food can be highly rewarding, and some proportion of over-consumption could be the results of self-medication of mental illness, such as depression and/or anxiety.

🏛️ Home/Virta.md

@@ -0,0 +1,11 @@
+# Points:
+
+- All points must be taken in the context that the sample population was self-selected and paying.
+- They counted improvements sustained by metformin toward their reversal statistic of 32.5%.
+- Complete remission without drugs was only 6.7% among completers, and 4.7% ITT (Table 1).
+- 45% of the participants started GLP1 agonists and another 10% increased their dosage (Fig. 3A).
+- Hba1c essentially returned to baseline despite subjects maintaining 50% of weight loss.
+	- Likely due to not reinstating medications.
+	- Difficult to make inferences about insulin sensitivity either way.
+- LDL was changed by 4.6 mg/dL, which is about half as much as is expected from going from the lowest to highest cholesterol intake.
+	- Not sure why we care about HDL, TG, or ApoA-1.