mirror of
https://gitlab.com/upRootNutrition/obsidian.git
synced 2025-06-16 18:05:13 -05:00
Initial commit
This commit is contained in:
commit
bc15d67574
1475 changed files with 1056167 additions and 0 deletions
61
🛡️ Debate/🗡️ Opponents/Dave Feldman.md
Normal file
61
🛡️ Debate/🗡️ Opponents/Dave Feldman.md
Normal file
|
@ -0,0 +1,61 @@
|
|||
# Lipid Triad
|
||||
|
||||
https://pubmed.ncbi.nlm.nih.gov/29241485/
|
||||
|
||||
"Many CVRF-free middle-aged individuals have atherosclerosis. LDL-C, even at levels currently considered normal, is independently associated with the presence and extent of early systemic atherosclerosis in the absence of major CVRFs. These findings support more effective LDL-C lowering for primordial prevention, even in individuals conventionally considered at optimal risk."
|
||||
|
||||
Lipid combos:
|
||||
https://pubmed.ncbi.nlm.nih.gov/25458651/
|
||||
|
||||
"Aside from isolated hypertriglyceridemia, low levels of HDL-C, high levels of LDL-C, and high levels of TG in any combination were associated with increased risk of CVD."
|
||||
|
||||
LMHR paper:
|
||||
https://pubmed.ncbi.nlm.nih.gov/35106434/
|
||||
|
||||
"These data suggest that, in contrast to the typical pattern of dyslipidemia, greater LDL cholesterol elevation on a CRD tends to occur in the context of otherwise low cardiometabolic risk."
|
||||
|
||||
---
|
||||
|
||||
# LDL Bounty
|
||||
|
||||
## Criteria
|
||||
|
||||
1. **HDL Cholesterol of 50 mg/dL or above (≥ 1.29 mmol/L)**
|
||||
2. **Triglycerides of 100 mg/dL or below (≤ 1.13 mmol/L)**
|
||||
3. **LDL Cholesterol of 130 mg/dL or above (≥ 3.36 mmol/L)**
|
||||
4. **Either high Coronary Heart Disease (CHD) or high Cardiovascular Disease (CVD) (see the section below)**
|
||||
5. By “**normal**” and “**non-treated**“, I mean:
|
||||
- No stratifying by specific genetics
|
||||
- No stratifying by drugs (no drug studies)
|
||||
- No stratifying by a particular illness in advance of the study. (duh!)
|
||||
- _In other words, just a generally broad group of people like [Framingham Offspring](https://www.ncbi.nlm.nih.gov/pubmed/27166203) or the [Jeppesen study](https://www.ncbi.nlm.nih.gov/pubmed/11176761)_
|
||||
6. And here’s some fine print that should be obvious, but just in case…
|
||||
- The study needs to be published in a reputable journal
|
||||
- It has to be dated before this article was posted, of course
|
||||
- The study needs to have at least 400 participants that are stratified by this criteria. (The two studies above have over 500)
|
||||
- I’d prefer no unusual “modeling” or “adjustments” to alter the data too far from it’s original set. This one goes by the honor system — if you have such a study and it is clearly warranted, I can give it a pass.
|
||||
|
||||
"High" defined as greater than the average rates of CVD per age group in the American population.
|
||||
|
||||
### Criticisms
|
||||
|
||||
1. Vanishingly small population subset. Unreasonable to expect it to have been studied.
|
||||
2. If studied in the general population, they won't be keto, so translation to keto subjects may be dubious.
|
||||
3. The sheer weight of the evidence in favour of LDL's causal role in ASCVD cuts deeply against the notion that this population subset would be protected to begin with.
|
||||
4. Comparing this isolated cohort to the American general population is methodology that is beyond fringe, bordering on insane.
|
||||
5. Ultimately if this is taken to be an indication that LDL is fine in this particular context, it would qualify as an appeal to ignorance.
|
||||
|
||||
---
|
||||
|
||||
# Hashtags
|
||||
|
||||
#lipidology
|
||||
#lipid_triad
|
||||
#LMHR
|
||||
#LDL
|
||||
#triglycerides
|
||||
#HDL
|
||||
#clowns
|
||||
#clownery
|
||||
#debate
|
||||
#debate_opponents
|
Loading…
Add table
Add a link
Reference in a new issue