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💻 Hyperblog/Work/coronary heart disease.md
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# Coronary Heart Disease
Coronary heart disease (CHD) is a condition where the coronary arteries, which supply oxygen-rich blood to the heart muscle, become narrowed or blocked due to the buildup of plaque, known as [[atherosclerosis]]. This reduction in blood flow can cause chest pain (angina), shortness of breath, and other symptoms. This can be caused by various factors including genetic predisposition, poor [[lifestyle]] habits, such as following a [[standard american diet]], and underlying medical conditions.****
Coronary heart disease (CHD) is a condition where the coronary arteries, which supply oxygen-rich blood to the heart muscle, become narrowed or blocked due to the buildup of plaque, known as [[atherosclerosis]]. This reduction in blood flow can cause chest pain (angina), shortness of breath, and other symptoms. This can be caused by various factors including genetic predisposition, poor [[lifestyle]] habits, such as following a [[standard american diet]], and underlying medical conditions.
**Key features of coronary heart disease:**

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💻 Hyperblog/Work/seed oil claims - cholestasis.md
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## Rebuttal
While partially true, this claim counts as a [[red herring]], because it's not actually seed oils simpliciter that causes [[cholestasis]]. In the [[LA Veterans Administration Hospital Study]], the seed oil group had a dose-dependent increase in gallstones [(1)](https://pubmed.ncbi.nlm.nih.gov/4681896/). However, the most parsimonious way of explaining the effect is through hepatic [[phytosterol]] elimination leading to gallstones, not [[linoleic acid]] [(2)](https://pubmed.ncbi.nlm.nih.gov/9437703/)[(3)](https://pubmed.ncbi.nlm.nih.gov/27812789/).
While partially true, this claim counts as a [[red herring]], because it's not actually seed oils simpliciter that causes [[cholestasis]]. In the [[LA Veterans Administration Hospital Study]], the seed oil group had a dose-dependent increase in gallstones [(1)](https://pubmed.ncbi.nlm.nih.gov/4681896/). However, the most parsimonious way of explaining the effect is through the elimination of hepatic [[phytosterols]], leading to gallstones, not [[linoleic acid]] [(2)](https://pubmed.ncbi.nlm.nih.gov/9437703/)[(3)](https://pubmed.ncbi.nlm.nih.gov/27812789/).
Some seed oils, such as corn oil (the primary seed oil investigated in the LA Veterans trial), have extremely high concentrations of [[phytosterols]] [(4)](https://pubmed.ncbi.nlm.nih.gov/31404986/). At the doses investigated, this may be expected to cause issues, but these are not doses that people typically consume, even on the [[standard american diet]].
Some seed oils, such as corn oil (the primary seed oil investigated in the LA Veterans trial), have extremely high concentrations of phytosterols [(4)](https://pubmed.ncbi.nlm.nih.gov/31404986/). At the doses investigated, this may be expected to cause issues, but these are not doses that people typically consume, even on the [[standard american diet]].
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