feat: added hyperblog

💻 Hyperblog/Work/proteoglycans.md

@@ -0,0 +1,45 @@
+
+# Proteoglycans
+
+Proteoglycans are complex macromolecules that play crucial roles in various tissues, including the subendothelial space of arteries.
+
+General structure of proteoglycans:
+
+1. Core protein.
+2. One or more glycosaminoglycan (GAG) chains covalently attached.
+3. GAGs are long, unbranched polysaccharides with repeating disaccharide units.
+
+Proteoglycans in the subendothelial space of arteries:
+
+1. Main types:
+    - Versican (large aggregating proteoglycan).
+    - Biglycan and decorin (small leucine-rich proteoglycans).
+    - Perlecan (basement membrane proteoglycan).
+2. Functions:
+    - Structural support and tissue organization.
+    - Regulation of water content and tissue hydration.
+    - Interaction with lipoproteins, particularly [[low-density lipoproteins]].
+    - Modulation of cell adhesion and migration.
+    - Regulation of growth factor activity.
+3. Role in atherosclerosis:
+    - Retention of [[apolipoprotein B-containing lipoproteins]].
+    - Contribution to the formation of [[atherosclerotic plaques]].
+    - Modulation of inflammatory responses.
+4. Interactions:
+    - Bind to other extracellular matrix components (e.g., collagen, elastin).
+    - Interact with cell surface receptors.
+    - Sequester growth factors and cytokines.
+5. Regulation:
+    - Synthesis and degradation influenced by mechanical forces, growth factors, and inflammatory mediators.
+
+Understanding the role of proteoglycans in the [[subendothelial space]] is crucial for comprehending arterial physiology and pathophysiology, particularly in the context of atherosclerosis development.
+
+---
+
+# Hashtags
+
+#proteoglycans 
+#subendothelial_space
+#low-density_lipoproteins 
+#heart_disease 
+#hyperblog