feat: added hyperblog

💻 Hyperblog/Work/atherosclerosis.md

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+# Atherosclerotic Cardiovascular Disease
+
+Atherosclerosis is a progressive, inflammatory disease of the arteries that develops over many years. This can be due to various factors including genetic predisposition, poor [[lifestyle]] habits, such as following a [[standard american diet]], and underlying medical conditions. It typically begins with endothelial dysfunction (though not always), allowing [[lipoproteins]], particularly [[low-density lipoproteins]], to accumulate in the arterial wall [(1)](https://pubmed.ncbi.nlm.nih.gov/34773457/)[(2)](). This triggers an inflammatory response, leading to a cascade of events:
+
+- Recruitment of immune cells, especially monocytes, which differentiate into macrophages.
+- Formation of foam cells as macrophages engulf [[oxidized low-density lipoproteins]].
+- Migration and proliferation of smooth muscle cells from the media to the [[subendothelial space]].
+- Production of extracellular matrix, forming a fibrous cap over the lipid-rich core.
+
+**Key features of atherosclerosis:**
+
+- Narrowing of the artery lumen, potentially restricting blood flow.
+- Rupture and subsequent thrombosis, leading to a [[heart attack]].
+- Chronic inflammatory process.
+- Affects various arterial beds (coronary, cerebral, peripheral).
+- Major cause of cardiovascular diseases.
+- Influenced by multiple risk factors (e.g., dyslipidemia, hypertension, smoking, diabetes).
+
+Management focuses on risk factor modification through lifestyle changes and pharmacological interventions. The goal is to slow progression, stabilize plaques, and prevent complications like myocardial infarction and stroke.
+
+# References
+
+1. https://pubmed.ncbi.nlm.nih.gov/34773457/
+2. https://pubmed.ncbi.nlm.nih.gov/32052833/
+
+---
+
+# Hashtags
+
+#cardiovascular_disease 
+#atherosclerosis
+#heart_disease 
+#low-density_lipoproteins 
+#inflammation
+#subendothelial_space 
+#heart_attack
+#oxidized_low-density_lipoproteins
+#cholesterol 
+#hyperblog