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32 lines
1.3 KiB
Markdown
32 lines
1.3 KiB
Markdown
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# Claim
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>Seed oils are unhealthy because they cause cholestasis.
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## Rebuttal
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While partially true, this claim counts as a [[red herring]], because it's not actually seed oils simpliciter that causes [[cholestasis]]. In the [[LA Veterans Administration Hospital Study]], the seed oil group had a dose-dependent increase in gallstones [(1)](https://pubmed.ncbi.nlm.nih.gov/4681896/). However, the most parsimonious way of explaining the effect is through hepatic [[phytosterol]] elimination leading to gallstones, not [[linoleic acid]] [(2)](https://pubmed.ncbi.nlm.nih.gov/9437703/)[(3)](https://pubmed.ncbi.nlm.nih.gov/27812789/).
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Some seed oils, such as corn oil (the primary seed oil investigated in the LA Veterans trial), have extremely high concentrations of [[phytosterols]] [(4)](https://pubmed.ncbi.nlm.nih.gov/31404986/). At the doses investigated, this may be expected to cause issues, but these are not doses that people typically consume, even on the [[standard american diet]].
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---
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## References
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1. https://pubmed.ncbi.nlm.nih.gov/4681896/
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2. https://pubmed.ncbi.nlm.nih.gov/9437703/
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3. https://pubmed.ncbi.nlm.nih.gov/27812789/
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4. https://pubmed.ncbi.nlm.nih.gov/31404986/
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---
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# Hashtags
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#cholestasis
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#claims
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#gallstones
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#la_veterans
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#liver_function
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#phytosterols
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#red_herring
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#seed_oils
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#hyperblog
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