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75 lines
4.3 KiB
Markdown
75 lines
4.3 KiB
Markdown
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Alami, Farkhondeh, et al. ‘The Effect of a Fruit-Rich Diet on Liver Biomarkers, Insulin Resistance, and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial’. _Scandinavian Journal of Gastroenterology_, June 2022, pp. 1–12. _PubMed_, https://doi.org/10.1080/00365521.2022.2071109.
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**Link:**
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https://pubmed.ncbi.nlm.nih.gov/35710164/
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**Calorie Intake Differences:**
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![[Pasted image 20220728110640.png]]
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**Notes:**
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- [[Roy Taylor's work on T2DM]] suggests that there may be a sigmoidal relationship between liver fat and BMI.
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**Conclusions:**
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>In conclusion, the present study found that 6 months of
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intervention with FRD exacerbated steatosis, dyslipidemia,
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and glycemic control of NAFLD patients. It is possible that
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excessive fruit consumption makes worse the condition of
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patients with fatty liver. According to the findings of the
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study, fruits intake increases the fat content of the hepatocyte probably through the lipogenic effect of fructose. To
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clarify the issue, more studies specifying a range for fruit
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intake (with minimum and maximum values) and considering
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obese patients and patients with different grades of fatty
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liver are warranted.
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**PDF:**
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[[📂 Media/PDFs/The effect of a fruit-rich diet on liver biomarkers, insulin resistance, and lipid profile in patients with non-alcoholic fatty liver disease- a randomized clinical trial.pdf]]
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**Supplements:**
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| **Endpoints** | **Exposures** | **Populations** | **General** | **People** |
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| -------------------- | ------------- | --------------- | ---------------- | ---------- |
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| #liver_enzymes | #fruit | #humans | #nutrition | |
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| #insulin_sensitivity | | | #clinical_trials | |
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| #blood_glucose | | | #disease | |
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| #insulin | | | #non_alcoholic_fatty_liver_disease | |
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| | | | #clown_papers | |
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| | | | #clownery | |
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****
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Johnston, Richard D., et al. ‘No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men’. _Gastroenterology_, vol. 145, no. 5, Nov. 2013, pp. 1016-1025.e2. _DOI.org (Crossref)_, https://doi.org/10.1053/j.gastro.2013.07.012.
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**Link:**
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https://pubmed.ncbi.nlm.nih.gov/23872500/
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****
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**Conclusions:**
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>Features of NAFLD including steatosis, and elevated serum transaminases and
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triglycerides occurred during energy overfeeding. The present study reports no difference in
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these parameters between fructose and glucose. The greater uric acid concentration with
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fructose was evidence of a reduced pre pyruvate metabolic control, though it appears to have
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no hepatic impact in terms of hepatic volume, TAG storage, insulin resistance, glycogen
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synthesis, fasted ATP content, and biochemical assays of liver function. As such, any advice on
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low fructose diets in NAFLD remains unjustified. Further assessments are needed to assess if
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the energy overfeeding changes are monosaccharide specific, and to assess the outcomes of
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low monosaccharide intakes in NAFLD patients.
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**PDF:**
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[[📂 Media/PDFs/j.gastro.2013.07.012.pdf]]
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| **Endpoints** | **Exposures** | **Populations** | **General** | **People** |
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| -------------- | ------------- | --------------- | ---------------- | ---------- |
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| #non_alcoholic_fatty_liver_disease | #glucose | #humans | #disease | |
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| #liver_enzymes | #fructose | | #clinical_trials | |
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| | | | #nutrition | |
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****
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